Search results for "Sodium borotritide"
showing 2 items of 2 documents
Radioactively labelled epoxides. part V. Tritium labelled K-region oxides and trans-dihydrodiols of pyrene, benzo[a]pyrene and dibenz[a, h]anthracene
1987
Tritium labelled K-region oxides of pyrene, benzo[a]pyrene and dibenz[a,h]anthracene have been prepared by cyclization of the corresponding trans-dihydrodiols which were obtained by reduction of K-region quinones with sodium borotritide in the presence of oxygen. This synthetic pathway not only yields two metabolically important radioactively labelled derivatives of polycyclic aromatic hydrocarbons in a simple and efficient manner, but also requires a rather inexpensive source of tritium.
Radioactively labelled epoxides. Part VI. tritium-labelled mono- and dimethyl substituted phenyl oxiranes (styrene oxides)
1988
Tritium-labelled (E)- and (Z)-2,3-dimethyl-2-phenyl oxirane 4, (E)- and (Z)-2-methyl-3-phenyl oxirane 7 and 2,2-dimethyl-3-phenyl oxirane 11 have been prepared by reduction of the corresponding bromoketones with sodium borotritide to the corresponding bromohydrins followed by cyclization to the oxiranes. These oxiranes were successfully used as diagnostic substrates to distinguish between different forms of epoxide hydrolase and glutathione transferase.